LSG Investments

Overview

LSG Investments is an evergreen venture fund dedicated to advancing healthcare by investing in early-stage life sciences technologies. The firm focuses on strengthening Pennsylvania's life sciences ecosystem and improving global healthcare outcomes by providing early-stage capital and operational expertise. LSG Investments bridges the gap between pre-seed and Series B funding, typically investing between $250,000 and $500,000 in seed-stage and Series A rounds, with the potential for follow-on investments up to $5 million. The firm seeks companies involved in drug discovery, diagnostics, medical devices, and IT-driven solutions to large-scale healthcare challenges. Since its inception in 2002, LSG Investments has invested over $44 million into 86 companies and projects, contributing to the creation and retention of more than 1,850 direct and indirect jobs in Pennsylvania. Their portfolio companies have attracted $773 million in follow-on funding, further strengthening the state's position in the life sciences ecosystem and advancing patient care beyond its borders.

Investment Focus

• Companies with demonstrated proof-of-concept
• Ties to Pennsylvania through headquarters, leadership, or institutional spin-outs
• Focus on drug discovery, diagnostics, medical devices, or IT-driven healthcare solutions